As Eminem succeeded in multi-platinum record sales, Interscope granted him his own record label. He and his manager Paul Rosenberg created Shady Records in late 2000. He followed this by signing his own Detroit collective D12 and rapper Obie Trice to the label. In 2002, Eminem signed 50 Cent through a joint venture between Shady and Dr. Dre's Aftermath label. In 2003, Eminem and Dr. Dre signed on Atlanta rapper Stat Quo to the Shady/Aftermath roster. DJ Green Lantern, the former DJ for Eminem, was signed to Shady Records until a dispute related to the 50 Cent and Jadakiss feud forced him to depart from the label; he is no longer associated with Eminem. The Alchemist is now officially Eminem's tour DJ. In 2005, Eminem signed another Atlanta rapper, Bobby Creekwater, to his label along with West Coast rapper Cashis.
On December 5, 2006, Shady Records released compilation album entitled Eminem Presents: the Re-Up. It started out as a mixtape but Eminem found that the material was better than expected and released it as a full album. It was meant to help launch the new artists under the roster, like Stat Quo, Cashis and Bobby Creekwater.